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Original Research Article | OPEN ACCESS

Amygdalin suppresses the proliferation, migration and EMT of gastric cancer cells by inhibiting TGF-β/Smad signal pathway

Junwei Xu1, Ning Qin2 , Wenbo Jiang3, Tao Chen1

1Department of Traditional Chinese Medicine, Affiliated Hospital of Nantong University, Nantong, China; 2Department of Medical Nursing Teaching and Research, Nantong Health College of Jiangsu Province, Nantong, Jiangsu Province 226001, China; 3Department of Cardiovascular Medicine, Suqian Hospital of Traditional Chinese Medicine, Suqian City, Jiangsu Province 223800, China.

For correspondence:-  Ning Qin   Email: qinning1635@163.com   Tel:+8615006289067

Accepted: 15 March 2022        Published: 30 April 2022

Citation: Xu J, Qin N, Jiang W, Chen T. Amygdalin suppresses the proliferation, migration and EMT of gastric cancer cells by inhibiting TGF-β/Smad signal pathway. Trop J Pharm Res 2022; 21(4):721-726 doi: 10.4314/tjpr.v21i4.6

© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effects of amygdalin on the proliferation, motility and epithelial mesenchymal transformation (EMT) of gastric cancer cells and to elucidate the operating mechanisms of action.
Methods: Gastric cancer AGS cells were treated with amygdalin (2.5, 5 and 10 mg/L). MTT and colony formation assays were used to investigate the effect of amygdalin on gastric cancer cell proliferation, while wound healing and Transwell assays were also carried out to determine its effect on the motility of gastric cancer cells. Immunoblot assays were used to investigate the effects of amygdalin on epithelial mesenchymal transformation (EMT) process and TGF-β/Smad pathway in gastric cancer cells.
Results: Treatment with amygdalin suppressed the proliferation of gastric cancer AGS cells (p < 0.05). Amygdalin suppressed the migration and invasion of AGS cells in vitro (p < 0.05). Additionally, amygdalin suppressed epithelial mesenchymal transformation (EMT) in AGS cells, and suppressed TGF-β/Smad pathway (p < 0.05), thereby suppressing growth, motility, and EMT in AGS cells.
Conclusion: Amygdalin may be useful for the treatment of gastric cancer; however, further studies are required ascertain this.

Keywords: Gastric cancer, Amygdalin, Proliferation, Epithelial mesenchymal transformation (EMT), TGF-β/Smad pathway

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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